How does PBM / Photobiomodulation Therapy work?

Photobiomodulation (PBM Therapy) previously known as Low Level Laser Therapy (LLLT) has a photochemical effect (like photosynthesis in plants). One of the main mechanisms of action occurs in the mitochondria (the cellular power plant inside every cell). The effect depend on the application of the correct wavelength and density of light, delivered to the target tissues for an appropriate period of time (typically between 30 - 60 seconds). Pulses can improve tissue repair and anti-inflammatory effect, analgesia is best achieved with a continuous beam.

TISSUE REPAIR AND ANTI-INFLAMMATORY EFFECTS

The primary effect occurs when light is absorbed in cytochrome c oxidase a protein within the mitochondria.

When cells get stressed (perhaps due to disease, injury or ageing) the mitochondria produces nitric oxide (NO). This competitively displaces oxygen from cytochrome c oxidase consequently reducing ATP (an essential intracellular cellular energy and extracellular signalling molecule) and causing an over production reactive oxygen species (ROS) and leading to oxidative stress. Oxidative stress is well known to lead to inflammation an cell death via the gene transcription factor NF-Kb.

PBM of the correct wavelength and density, dissociates NO allowing oxygen back in, so ATP is restored and oxidative stress reduced. Once normal mitochondrial function is restored by PBM then cell metabolism is improves, and the patient gets better more quickly.

Benefits of PBM

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How does PBM Work?

What are the benefits of PBM?

What are the contra-indications of PBM?

3B vs Class IV Lasers

Calculating PBM Dosage

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THOR Photomedicine Ltd is an ISO 13485:2016 certified medical device company.

The THOR LX2.3 Photobiomodulation system has a medical CE mark (EC certificate). It is indicated for oral mucositis, tendinopathies, joint pain, neck pain and back pain for marketing in the UK, EU and Australia.

The THOR LX2.3 Photobiomodulation system is also FDA Cleared for marketing in the United States for: Temporary increase in local blood circulation, temporary relief of minor muscle and joint aches, pains and stiffness and relaxation of muscles; for muscle spasms, and minor pain and stiffness associated with arthritis.

Excluding the THOR LED Helmet, THOR LX2 and NovoTHOR systems are manufactured under conditions fulfilling the quality system requirements of Annex II, excluding (4), of the directive 93/42/EEC as amended and satisfy the applicable international harmonised standards.

Positive systematic reviews published by:

The British Medical Journal (BMJ), The Lancet, the International Association for the Study of Pain (IASP), the World Health Organisation (WHO), the Multinational Association for Supportive Care in Cancer (MASCC), the European Society for Medical Oncology (ESMO)

Appropriate regulatory clearance or approvals include:

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How does PBM / Photobiomodulation Therapy work?

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